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Ninety-eight patients with multiple sclerosis(MS)in the chronic progression phase entered a 3-year clinical trial to determine if azathioprine(AZ)alone or with adrenal cortical steroids stabilized the course of MS.In group AM,the patients took AZ throughout and methylprednisolone(MP)for the first 36 weeks.Group AP received AZ and placebo instead of MP.Group PP took placebos for both drugs.We adjusted the AZ to maintain the total white blood cell count within 3,000 to 4,000/ mm;we gave the MP in a fixed dose"pulse"and alternate-day regimen.The" intent-to-treat"groups had no statistically significant differences in the rates of progression among the 3 treatments.Subgroups analysis suggests that patients in the AM group who completed treatment exactly according to protocol did statistically significantly better than the placebo recipients using the sum of Standard Neurological Examination scores, slightly better using the quantitative neuro-performance tests,but no better using Mickey's Illness Severity Scores or Kurtzke's Disability Status Scale.Also,the AZ-treated groups had half the relapse rate of the placebo-treated group.Adverse reactions to AZ accounted for most withdrawals.Hematologic and hepatic abnormalities were significantly associated with AZ,but serious non-MS abnormalities were uncommon and were equally distributed among the 3 groups.Addition of MP to the AZ slightly improved the efficacy of the treatment,but also increased the adverse effects.The benefits of AZ with or without steroids did not outweigh the risks,and therefore we do not recommend this treatment for patients with chronic progressive MS. |
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azathioprine
immunosuppressive agents
multiple sclerosis
multiple sclerosis,chronic progressive
multiple sclerosis,treatment of
steroid
steroid therapy,CNS treatment and complications with
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